Danielle Christine Fishel was born on May 5, 1981, in Mesa, Arizona. She began acting professionally at the age of ten, during which she made many TV guest appearances and commercials. She was originally a guest star on the show Boy Meets World (1993), but Danielle added a spark that the show needed and she became a regular cast member shortly afterward. She played Topanga Lawrence on the show, the girlfriend of Cory Matthews. The show brought Danielle much attention even landing her face on the cover of "Seventeen" magazine. She was voted as one of Teen People's magazine hottest stars under the age of 21. She graduated from high school in 1999.

In 2014, fourteen years after the conclusion of "Boy," she reprised her role as Topanga, now the wife of Cory Matthews, in the show Girl Meets World (2014).